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Posted on: 25-10-14
Light-activated drug to help control diabetes

Scientists have come out with a special drug for Type 2 diabetes that has been triggered on by blue light, thus paves the way to reducing the ill-effects and side-effects of diabetes medication. The drug would have less effect and may turn inactive under normal circumstances and conditions. But the patient can very well switch it on using blue LEDs that is attached to the skin.

A very small spark of light would be required to penetrate deep into the skin in order to change the shape of the drug and finally turns it on.
When the light goes off, the change becomes reversible and again the drug switches off.
Diabetes drugs that promotes the release of insulin from the body(in pancreas) can in many a times cause side effects because of the actions on organs such as brain and heart.
Some can also stimulate too much insulin release, causing blood sugar levels to drop too low," explained David Hodson from the Imperial College London.

They demonstrated that the prototype drug, known as JB253, stimulates insulin release from pancreatic cells in the lab when exposed to blue light.

"In principle, this type of therapy may allow better control over blood sugar levels because it can be switched on for a short time when required after a meal. It should also reduce complications by targeting drug activity to where it's needed in the pancreas," Hodson informed."So far, we have created a molecule that has the desired effect on human pancreatic cells in the lab. Our ultimate goal is to make this therapy available to patients soon," he noted.

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