Spinal implant could allow paralyzed people to walk again
Scientists have used a new flexible implant to allow paralyzed rats to walk again, paving the way for new therapies for people with spinal cord injury. The e-Dura implantdeveloped by Swiss Federal Institute of Technology Lausanne (EPFL) scientists can be applied directly to the spinal cord without causing damage and inflammation.
EPFL scientists have managed to get rats walking on their own again using a combination of electrical and chemical stimulation. But applying this method to humans would require multi-functional implants that could be installed for long periods of time on the spinal cord without causing any tissue damage, researchers said. The implant developed by the teams of professors Stephanie Lacour and Gregoire Courtine is designed specifically for implantation on the surface of the brain or spinal cord.
Flexible and stretchy, the implant developed at EPFL is placed beneath the dura mater, directly onto the spinal cord. Its elasticity and its potential for deformation are almost identical to the living tissue surrounding it. This reduces friction and inflammation to a minimum. When implanted into rats, the e-Dura prototype caused neither damage nor rejection, even after two months. The researchers tested the device prototype by applying their rehabilitation protocol- which combines electrical and chemical stimulation-to paralyzed rats.
Study identifies genetic mutation in those who behave reckless when drunk
University of Helsinki researchers have identified a genetic mutation which renders carriers susceptible to particularly impulsive and reckless behavior when drunk. More than one hundred thousand Finns carry this mutation. Many Finns know somebody whose behavior becomes excessively strange and erratic when drunk. They are said to be unable to "hold their liquor," and others are surprised at how inebriated they become from just a small amount of alcohol. Since the trait seems permanent, it can be assumed that there are underlying biological factors.
If these results prove significant in larger clinical samples of individual patients who suffer greatly from difficulties in impulse control, several preventive measures could be taken. The most important measure would obviously be controlling the consumption of alcohol. Other measures would include attempting to achieve control over behavior through cognitive-behavioral psychotherapy or medication.
Apart from the putative effect on the health of Finnish population, the discovery of this biological mechanism may be groundbreaking in understanding the role of the serotonin 2B receptor in humans. Novel neurobiological research is becoming increasingly aware of the fact that the expression of a gene -- that is, the gene's production of proteins can be affected in various ways. The findings may elucidate the role of the serotonin 2B receptor in the health of any given population. Moreover, increasing knowledge of the function of the serotonin 2B receptor may lead to new pharmacological innovations, since no medications specific to it are presently available.
The discovery is based on long-term research cooperation between the University of Helsinki Psychiatry Clinic and the Dr David Goldman's laboratory of Neurogenetics at the National Institute on Alcohol Abuse and Alcoholism in the United States.
Taking medication to newer level
A craftsman made a living duplicate of Vincent Van Gogh's ear utilizing a 3-D printer. It may not set the craftsmanship world on its ear, yet 3-D printing could take drug to another level. It is now yielded skin, bone, veins, heart and liver, and also made-to-request non-natural appendages and surgical implants. Furthermore, an ear, developed from the DNA of van Gogh's sibling's great grandson. Right now it is possible with working human organs.
One day you'll have the capacity to regrow lost bone. Body shops - those that handle the repair of harmed and broken-down people, not autos - will have parts more approaches to settle your case. Researchers now can make exclusively fitted molds for parts of your skeleton and joints. They utilize stem cells of adult to develop bone and ligament to fill in shabby or broken, repair breaks, and seal the cracks.
Shots loaded with to a great degree small robots may get to be a piece of your yearly health schedule. Nanobots, littler than cells, can be customized to act like robocops to protect against infections and mutated cells, to search them in the body and to free you of intruders. Later on, specialists will draw robot-rich arrangements into syringes and infuse them into your body. These protectors will shroud themselves to survive your defense mechanism and after that make and convey medication.
Not long from now, here is the manner by which treatment will enhance for a wide range of growth. Specialists can as of now distinguish qualities that cause numerous sorts of acquired disease and they are endeavoring to nail down the rest. Medications tomorrow will be more customized, custom-made, and intended to hit the exact targets - from cells to the molecules inside them. The reactions of new medications will be a great deal less extreme than today's chemo.
Sleep disorders in kids linked to behavioral problems
Parents may please take note that toddlers having sleep difficulties are likely to experience behavioural problems.
Early sleep problems may be both a cause and consequence of children's difficulties with behavioural and emotional self-regulation, a study showed.
Inadequate sleep is associated with daytime sleepiness, less optimal pre-school adjustment and problems of irritability, hyperactivity and attention, the study noted.
"Essentially, these young children might be caught in a cycle, with sleep disruption affecting their psychiatric symptoms and psychiatric symptoms affecting their sleep-wake organisation," explained John Boekamp from Bradley Hospital, Rhode Island in the US.
"Sleep problems in young children frequently co-occur with other behavioural problems, with evidence that inadequate sleep is associated with daytime sleepiness, less optimal pre-school adjustment, and problems of irritability, hyperactivity and attention."
This study examined the nature and prevalence of diagnostically defined sleep disorders, including Sleep Onset Insomnia and Night Waking Insomnia, in a group of 183 young children.
Sleep problems were especially common in children with disruptive behaviour, attention, anxiety and mood problems."It is important for families to be aware of how important sleep is to the behavioural adjustment and well being of young children," Boekamp pointed out.The study was published online in the journal Child Psychiatry & Human Development.
Olive oil may revive a failing heart
A new research has suggested that a strong ingredient in olive oil will hold the key to a beating heart failure. Researchers have also found that, a very commonly found dietary fat called the Oleate, mostly found in olive oil, re fixed and restored proper metabolism of fuel in heart cells in an animal model.
Heart failure and heart attack are entirely two different things. Heart failure is a more fatal or chronic disease condition wherein the heart becomes more bigger and it requires the heart to work harder to pump blood.
As the walls of heart grow thicker, the amount of blood being pumped out comes down or gets diminished and can hence no longer provide the body with enough nutrients. Heart which is on the verge of failing are also unable to function or store the fats that they use for fuel, which are contained within small droplets called lipid bodies in hear muscle cells.
Fats are the primary fuel source of heart and the inability to use those fats, causes the muscle to become starved for energy. Fats failing hearts manage to cut short itself or break down into toxic intermediary by-products that may later on lead to major heart ailments.
Oleate contained in olive oil accelerated the activation level of several genes for enzymes that metabolizes fats. "This gives more proof to the idea that consuming healthy fats like oleate can have a significantly positive effect on cardiac health," Lewandowski said. The findings were published in the journal Circulation.