We are aware of the fact that malaria
parasites conquerers the human immune system
while being in human red blood cells. According to a very new study, blood type O provides protection and resistance against malaria.
The study suggests that a protein secreted by parasites called RIFIN, plays an important role in providing protection against malaria in people who have blood group O.
A team of Scandinavian scientists explains the mechanisms behind the protection that blood type O provides and suggests that the selective pressure imposed by malaria may contribute to the variable global distribution of ABO blood groups in the human population.
It has long been known that people with blood type O are protected against severe malaria, while those with other types, such as A, often fall into a coma and die. Unpacking the mechanisms behind this has been one of the main goals of malaria research.
Scientists led from Karolinska Institutet in Sweden have now identified a new and important piece of the puzzle by describing the key part played by the RIFIN protein.
Using data from different kinds of experiment on cell cultures and animals, they show how the Plasmodium falciparum parasite secretes RIFIN, and how the protein makes its way to the surface of the blood cell, where it acts like glue. The team also demonstrates how it bonds strongly with the surface of type A blood cells, but only weakly to type O.